A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia.

A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia.

BACKGROUND:Posaconazole (POS) is a potent triazole antifungal agent approved in adults for treatment and prophylaxis of invasive fungal infections (IFIs). The objectives of this study were to evaluate the pharmacokinetics (PK), safety, and tolerability of POS oral suspension in pediatric subjects wi...

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Bibliographic Details
Main Authors: Antonio C Arrieta, Lillian Sung, John S Bradley, C Michel Zwaan, Davis Gates, Hetty Waskin, Patricia Carmelitano, Andreas H Groll, Thomas Lehrnbecher, Eric Mangin, Amita Joshi, Nicholas A Kartsonis, Thomas J Walsh, Amanda Paschke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212837

Internet

https://doi.org/10.1371/journal.pone.0212837

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