Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Abstract Background Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological processes. Here, we will investigate the effect of Shp2 inhibition on...

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Bibliographic Details
Main Authors: Yusheng Cheng, Min Yu, Jian Xu, Mengyu He, Hong Wang, Hui Kong, Weiping Xie
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Pulmonary Medicine
Subjects:
Shp2
Pulmonary vascular remodeling
Pulmonary hypertension
Online Access:http://link.springer.com/article/10.1186/s12890-018-0700-y

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http://link.springer.com/article/10.1186/s12890-018-0700-y

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