Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis. This study investigated whether acute blockade of the vasod...

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Bibliographic Details
Main Authors: Lakmie S. Gunarathne, Peter W. Angus, Chandana B. Herath
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
portal pressure
portal hypertension
mas receptor
Mas-related G-protein coupled receptor type D
angiotensin II type 1 receptor
cirrhosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01169/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01169/full

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