Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities

Right ventricular failure (RVF) remains the leading cause of death in pulmonary arterial hypertension (PAH). We investigated the transcriptomic signature of RVF in hemodynamically well-phenotyped monocrotaline (MCT)-treated, male, Sprague-Dawley rats with severe PAH and decompensated RVF (increased...

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Bibliographic Details
Main Authors: Francois Potus, Charles Colin Thomas Hindmarch, Kimberly J. Dunham-Snary, Jeff Stafford, Stephen L. Archer
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
transcriptomics
mitochondria
metabolism
TFAM
CYP2E1
GALNT13
ANXA1
periostin
LTBP2
THBS4
Online Access:http://www.mdpi.com/1422-0067/19/9/2730

Internet

http://www.mdpi.com/1422-0067/19/9/2730

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