The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B

The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B

Summary: AMFR/gp78 and USP13 are a pair of ubiquitin ligase and deubiquitinase that ensure the accuracy of endoplasmic reticulum-associated degradation (ERAD). Depletion of USP13 leads to caspase activation and cleavage of the ERAD chaperone BAG6, which is reversed by knockdown of AMFR. However, the...

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Bibliographic Details
Main Authors: Yuanyuan Chu, Xingqi Dong, Yingjin Kang, Jingnan Liu, Tao Zhang, Cuiwei Yang, Zhangshun Wang, Wangchen Shen, Huanhuan Huo, Min Zhuang, Junxia Lu, Yanfen Liu
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biological Sciences
Biochemistry
Molecular Biology
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309056

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http://www.sciencedirect.com/science/article/pii/S2589004220309056

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