Immune characteristics study of AG490, a signal pathway inhibitor, in EAE model mice

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination, axonal damage and progressive neurologic dysfunction in central nervous system (CNS). Many evidences show that B cells play an important role in the pathogenesis of MS. Follicular helper T cells (Tfh) secrete IL-21 to p...

Full description

Bibliographic Details
Main Authors: Zhihua Zhao, Zhifeng Mao, Junjie Yin, Yaqing Shu, Wei Qiu, Zhengqi Lu, Xueqiang Hu
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Saudi Journal of Biological Sciences
Subjects:
Tfh
EAE
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X16300961