High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice.

High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice.

G protein-coupled receptor 119 (GPR119) is highly expressed in pancreatic β cells and enteroendocrine cells. It is involved in glucose-stimulated insulin secretion and glucagon-like peptide-1 (GLP-1) release, thereby representing a promising target for the treatment of type 2 diabetes. Although a nu...

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Bibliographic Details
Main Authors: Meng Zhang, Yang Feng, Jia Wang, Jianwei Zhao, Ting Li, Min He, Dehua Yang, Olivier Nosjean, Jean Boutin, Pierre Renard, Ming-Wei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3660563?pdf=render

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http://europepmc.org/articles/PMC3660563?pdf=render

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