Collagen facilitates the colorectal cancer stemness and metastasis through an integrin/PI3K/AKT/Snail signaling pathway

Purpose: Dynamic remodeling of the extracellular matrix (ECM) around tumor cells is crucial for the tumor progressions. However, the mechanism is not well defined. Here, we aimed to reveal the underlying mechanism of ECM induced metastasis and provide innovative strategy to suppress the distant meta...

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Bibliographic Details
Main Authors: Xiangbin Wu, Jianhui Cai, Zhigui Zuo, Jinlei Li
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218376753