Activation of Myd88-Dependent TLRs Mediates Local and Systemic Inflammation in a Mouse Model of Primary Sjögren's Syndrome

Activation of Myd88-Dependent TLRs Mediates Local and Systemic Inflammation in a Mouse Model of Primary Sjögren's Syndrome

Toll-like receptors (TLRs) are important mediators of chronic inflammation in numerous autoimmune diseases, although the role of these receptors in primary Sjögren's syndrome (pSS) remains incompletely understood. Previous studies in our laboratory established Myd88 as a crucial mediator of pSS...

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Bibliographic Details
Main Authors: Jeremy Kiripolsky, Rose-Anne Romano, Eileen M. Kasperek, Guan Yu, Jill M. Kramer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
NOD.B10
decorin
B cell
salivary gland
TLR2
TLR4
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02963/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02963/full

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