Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia

Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia

Abstract Background Activation of NF-kappaB RelA deacetylated at the lysine residues, except the lysine 310, drives pro-apoptotic transcription in noxious brain ischemia. We showed that the sinergistic combination of the histone deacetilase inhibitor MS-275 with the sirtuin 1 activator resveratrol,...

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Bibliographic Details
Main Authors: Mariana Mota, Vanessa Porrini, Edoardo Parrella, Marina Benarese, Arianna Bellucci, Sina Rhein, Markus Schwaninger, Marina Pizzi
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
Inflammation
Microglia
NF-kB RelA
Resveratrol
MS-275
Online Access:https://doi.org/10.1186/s12974-020-02028-4

Internet

https://doi.org/10.1186/s12974-020-02028-4

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