1Q12 Loci Movement in the Interphase Nucleus Under the Action of ROS Is an Important Component of the Mechanism That Determines Copy Number Variation of Satellite III (1q12) in Health and Schizophrenia

1Q12 Loci Movement in the Interphase Nucleus Under the Action of ROS Is an Important Component of the Mechanism That Determines Copy Number Variation of Satellite III (1q12) in Health and Schizophrenia

Introduction: Genome repeat cluster sizes can affect the chromatin spatial configuration and function. Low-dose ionizing radiation (IR) induces an adaptive response (AR) in human cells. AR includes the change in chromatin spatial configuration that is necessary to change the expression profile of th...

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Main Authors: Marina Sergeevna Konkova, Elizaveta Sergeevna Ershova, Ekaterina Alekseevna Savinova, Elena Mikhailovna Malinovskaya, Galina Vasilievna Shmarina, Andrey Vladimirovich Martynov, Roman Vladimirovich Veiko, Nataly Vyacheslavovna Zakharova, Pavel Umriukhin, Georgy Petrovich Kostyuk, Vera Leonidovna Izhevskaya, Sergey Ivanovich Kutsev, Natalia Nikolaevna Veiko, Svetlana Victorovna Kostyuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CNVs
satellite III
rDNA
schizophrenia
1q12
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00386/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00386/full

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