Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent
<abstract language="eng">In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-meth...
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| Language: | English |
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Sociedade Brasileira de Química
2002-12-01
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| Series: | Química Nova |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018 |
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doaj-2d375d7d87fc43a3af7685e43ff1c987 |
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doaj-2d375d7d87fc43a3af7685e43ff1c9872020-11-24T23:58:40ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642002-12-01256b1172118010.1590/S0100-40422002000700018Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agentEliezer J. Barreiro<abstract language="eng">In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018new cardiotonic derivativebioactive N-acylhydrazone compoundLASSBio-294 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Eliezer J. Barreiro |
| spellingShingle |
Eliezer J. Barreiro Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent Química Nova new cardiotonic derivative bioactive N-acylhydrazone compound LASSBio-294 |
| author_facet |
Eliezer J. Barreiro |
| author_sort |
Eliezer J. Barreiro |
| title |
Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| title_short |
Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| title_full |
Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| title_fullStr |
Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| title_full_unstemmed |
Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo Strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| title_sort |
estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo strategy of molecular simplification in rational drug design: the discovery of a new cardioactive agent |
| publisher |
Sociedade Brasileira de Química |
| series |
Química Nova |
| issn |
0100-4042 1678-7064 |
| publishDate |
2002-12-01 |
| description |
<abstract language="eng">In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein. |
| topic |
new cardiotonic derivative bioactive N-acylhydrazone compound LASSBio-294 |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018 |
| work_keys_str_mv |
AT eliezerjbarreiro estrategiadesimplificacaomolecularnoplanejamentoracionaldefarmacosadescobertadenovoagentecardioativostrategyofmolecularsimplificationinrationaldrugdesignthediscoveryofanewcardioactiveagent |
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1725450323835748352 |