Effects of 2 Novel PYY(1-36) Analogues, (PLP)PYY(1-36) and PYY(1-36)(LysPAL), on Pancreatic Beta-Cell Function, Growth, and Survival

Recent studies have identified a beneficial role for peptide tyrosine tyrosine (PYY) on pancreatic beta-cell function and survival. These effects are linked to the activation of neuropeptide Y1 receptors (NPYR1s) by PYY(1-36). However, PYY(1-36) is subject to rapid degradation by dipeptidyl peptidas...

Full description

Bibliographic Details
Main Authors: Ryan A Lafferty, Victor A Gault, Peter R Flatt, Nigel Irwin
Format: Article
Language:English
Published: SAGE Publishing 2019-06-01
Series:Clinical Medicine Insights: Endocrinology and Diabetes
Online Access:https://doi.org/10.1177/1179551419855626