Selective constraint on noncoding regions of hominid genomes.
An important challenge for human evolutionary biology is to understand the genetic basis of human-chimpanzee differences. One influential idea holds that such differences depend, to a large extent, on adaptive changes in gene expression. An important step in assessing this hypothesis involves gainin...
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doaj-2d3f6e1c8bdd4550a48212b872b788c22020-11-25T01:57:35ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582005-12-0117e7310.1371/journal.pcbi.0010073Selective constraint on noncoding regions of hominid genomes.Eliot C BushBruce T LahnAn important challenge for human evolutionary biology is to understand the genetic basis of human-chimpanzee differences. One influential idea holds that such differences depend, to a large extent, on adaptive changes in gene expression. An important step in assessing this hypothesis involves gaining a better understanding of selective constraint on noncoding regions of hominid genomes. In noncoding sequence, functional elements are frequently small and can be separated by large nonfunctional regions. For this reason, constraint in hominid genomes is likely to be patchy. Here we use conservation in more distantly related mammals and amniotes as a way of identifying small sequence windows that are likely to be functional. We find that putatively functional noncoding elements defined in this manner are subject to significant selective constraint in hominids.http://europepmc.org/articles/PMC1314883?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eliot C Bush Bruce T Lahn |
spellingShingle |
Eliot C Bush Bruce T Lahn Selective constraint on noncoding regions of hominid genomes. PLoS Computational Biology |
author_facet |
Eliot C Bush Bruce T Lahn |
author_sort |
Eliot C Bush |
title |
Selective constraint on noncoding regions of hominid genomes. |
title_short |
Selective constraint on noncoding regions of hominid genomes. |
title_full |
Selective constraint on noncoding regions of hominid genomes. |
title_fullStr |
Selective constraint on noncoding regions of hominid genomes. |
title_full_unstemmed |
Selective constraint on noncoding regions of hominid genomes. |
title_sort |
selective constraint on noncoding regions of hominid genomes. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Computational Biology |
issn |
1553-734X 1553-7358 |
publishDate |
2005-12-01 |
description |
An important challenge for human evolutionary biology is to understand the genetic basis of human-chimpanzee differences. One influential idea holds that such differences depend, to a large extent, on adaptive changes in gene expression. An important step in assessing this hypothesis involves gaining a better understanding of selective constraint on noncoding regions of hominid genomes. In noncoding sequence, functional elements are frequently small and can be separated by large nonfunctional regions. For this reason, constraint in hominid genomes is likely to be patchy. Here we use conservation in more distantly related mammals and amniotes as a way of identifying small sequence windows that are likely to be functional. We find that putatively functional noncoding elements defined in this manner are subject to significant selective constraint in hominids. |
url |
http://europepmc.org/articles/PMC1314883?pdf=render |
work_keys_str_mv |
AT eliotcbush selectiveconstraintonnoncodingregionsofhominidgenomes AT brucetlahn selectiveconstraintonnoncodingregionsofhominidgenomes |
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1724973999806480384 |