Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia.

Microvascular endothelial cells play a pivotal role in the pathogenesis of sepsis-induced inflammatory responses and multiple organ failure. Therefore, they represent an important target for pharmacological intervention in the treatment of sepsis. Glucocorticosteroids were widely used in the treatme...

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Bibliographic Details
Main Authors: Ranran Li, Piotr S Kowalski, Henriëtte W M Morselt, Ilona Schepel, Rianne M Jongman, Adnan Aslan, Marcel H J Ruiters, Jan G Zijlstra, Grietje Molema, Matijs van Meurs, Jan A A M Kamps
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5953446?pdf=render

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http://europepmc.org/articles/PMC5953446?pdf=render

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