Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Summary: Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM4pos Kupffer cells (KCs) decrease in number, while monocyte-derived Tim4neg macrophages accumulate. In concer...

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Bibliographic Details
Main Authors: Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, Li He, Mandy M. Chan, Joseph W. Beals, Kim H. Liss, Samuel Klein, Ariel E. Feldstein, Brian N. Finck, Maxim N. Artyomov, Joel D. Schilling
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
Kupffer cells
inflammation
diabetes
liver
CCR2
crown-like structures
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316156

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http://www.sciencedirect.com/science/article/pii/S2211124720316156

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