A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
Here the authors describe a simple reverse genetics method that relies on overlapping cDNA fragments for generation of positive-strand viruses including SARS-CoV-2 and characterize them in vitro and in vivo.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-23779-5 |