Molecular Dynamics Simulations of Wild Type and Mutants of SAPAP in Complexed with Shank3

Molecular Dynamics Simulations of Wild Type and Mutants of SAPAP in Complexed with Shank3

Specific interactions between scaffold protein SH3 and multiple ankyrin repeat domains protein 3 (Shank3) and synapse-associated protein 90/postsynaptic density-95–associated protein (SAPAP) are essential for excitatory synapse development and plasticity. In a bunch of human neurological d...

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Bibliographic Details
Main Authors: Lianhua Piao, Zhou Chen, Qiuye Li, Ranran Liu, Wei Song, Ren Kong, Shan Chang
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
Shank3 and SAPAP interactions
molecular dynamics simulation
free energy calculation
conformational change
Online Access:http://www.mdpi.com/1422-0067/20/1/224

Internet

http://www.mdpi.com/1422-0067/20/1/224

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