Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway

Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway

Objective: Nicorandil exerts a protective effect against coronary microvascular dysfunction in acute myocardial infarction (AMI) patients. However, the mechanism and effect of nicorandil in hyperhomocysteinemia (HHcy) AMI patients remain unclear. Methods: C57/BL6 mice with mild to moderate HHcy and...

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Bibliographic Details
Main Authors: Biming Zhan, Zongyu Xu, Yang Zhang, Kefei Wan, Hanyue Deng, Dimeng Wang, Huihui Bao, Qinghua Wu, Xiaohong Hu, Hong Wang, Xiao Huang, Xiaoshu Cheng
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Nicorandil
Homocysteine
Coronary microvascular dysfunction
PI3K/Akt/eNOS pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303139

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http://www.sciencedirect.com/science/article/pii/S0753332220303139

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