Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives

Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives

In the present work, 12 novel Schiff’s bases containing a thiadiazole scaffold and benzamide groups coupled through appropriate pharmacophore were synthesized. These moieties are associated with important biological properties. A facile, solvent-free synthesis of a series of novel 7(a–l) N-((5-(subs...

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Bibliographic Details
Main Authors: Shailee V. Tiwari, Sumaiya Siddiqui, Julio A. Seijas, M. Pilar Vazquez-Tato, Aniket P. Sarkate, Deepak K. Lokwani, Anna Pratima G. Nikalje
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
microwave-assisted synthesis
thiadiazoles
in vitro anticancer activity
molecular docking
ADMET
Online Access:http://www.mdpi.com/1420-3049/22/6/995

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http://www.mdpi.com/1420-3049/22/6/995

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