Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice.

Deficient Mechanical Activation of Anabolic Transcripts and Post-Traumatic Cartilage Degeneration in Matrilin-1 Knockout Mice.

Matrilin-1 (Matn1), a cartilage-specific peri-cellular and extracellular matrix (ECM) protein, has been hypothesized to regulate ECM interactions and transmit mechanical signals in cartilage. Since Matn1 knock-out (Matn1-/-) mice exhibit a normal skeleton, its function in vivo is unclear. In this st...

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Bibliographic Details
Main Authors: Yupeng Chen, Jack Cossman, Chathuraka T Jayasuriya, Xin Li, Yingjie Guan, Vera Fonseca, Kun Yang, Cherie Charbonneau, Hongchuan Yu, Katsuaki Kanbe, Peter Ma, Eric Darling, Qian Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0156676

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https://doi.org/10.1371/journal.pone.0156676

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