A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development

Pax1 and Pax9 play redundant, synergistic functions in the patterning and differentiation of the sclerotomal cells that give rise to the vertebral bodies and intervertebral discs (IVD) of the axial skeleton. They are conserved in mice and humans, whereby mutation/deficiency of human PAX1/PAX9 has be...

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Bibliographic Details
Main Authors: V. Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, Thomas Lufkin
Format: Article
Language:English
Published: The Company of Biologists 2017-02-01
Series:Biology Open
Subjects:
Pax1
Pax9
Sox trio
Intervertebral disc
TGF-B
BMP
Online Access:http://bio.biologists.org/content/6/2/187

Internet

http://bio.biologists.org/content/6/2/187

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