Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

Transcriptional gene silencing (TGS) of mammalian genes can be induced by short interfering RNA (siRNA) targeting promoter regions. We previously reported potent TGS of HIV-1 by siRNA (PromA), which targets tandem NF-κB motifs within the viral 5′LTR. In this study, we screened a siRNA panel with the...

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Bibliographic Details
Main Authors: Chantelle Ahlenstiel, Catalina Mendez, Steven T H Lim, Katherine Marks, Stuart Turville, David A Cooper, Anthony D Kelleher, Kazuo Suzuki
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
epigenetics
heterochromatin
histone modifications
HIV-1
non-coding RNA
si/shRNA
transcriptional silencing
viral latency
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300464

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http://www.sciencedirect.com/science/article/pii/S2162253116300464

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