Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Drug-loaded, PEGylated, organic-modified silica (ORMOSIL) nanoparticles prepared by microemulsion condensation of vinyltriethoxysilane (VTES) were investigated as potential nanovectors for cancer therapy. To target cancer stem cells, anti-CD44v6 antibody and hyaluronic acid (HA) were conjugated to a...

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Bibliographic Details
Main Authors: Lucía Morillas-Becerril, Elektra Peta, Luca Gabrielli, Venera Russo, Elisa Lubian, Luca Nodari, Maria Grazia Ferlin, Paolo Scrimin, Giorgio Palù, Luisa Barzon, Ignazio Castagliuolo, Fabrizio Mancin, Marta Trevisan
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Nanomaterials
Subjects:
silica nanoparticles
targeted delivery
cd44 receptor
hyaluronic acid
antibodies
Online Access:https://www.mdpi.com/2079-4991/10/2/298

Internet

https://www.mdpi.com/2079-4991/10/2/298

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