Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

In this study, we demonstrate a newly derived mouse model that supports engraftment of human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) strain with the C57BL/6J-KitW-41J/J (C57BL/6.KitW41) strain and engraft, without irradiation,...

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Bibliographic Details
Main Authors: Brian E. McIntosh, Matthew E. Brown, Bret M. Duffin, John P. Maufort, David T. Vereide, Igor I. Slukvin, James A. Thomson
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114003828

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http://www.sciencedirect.com/science/article/pii/S2213671114003828

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