Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries

The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library...

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Bibliographic Details
Main Authors: David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
heterocyclic peptidomimetics
parallel synthesis
combinatorial chemistry
guanidines
solid-phase synthesis
antiplasmodial
malaria
Online Access:https://www.mdpi.com/1420-3049/24/6/1100

Internet

https://www.mdpi.com/1420-3049/24/6/1100

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