Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library...
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MDPI AG
2019-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/6/1100 |
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doaj-2d655bfb332b4b94a977f44bf46cb60a2020-11-24T21:21:42ZengMDPI AGMolecules1420-30492019-03-01246110010.3390/molecules24061100molecules24061100Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based LibrariesDavid L. Perry0Bracken F. Roberts1Ginamarie Debevec2Heather A. Michaels3Debopam Chakrabarti4Adel Nefzi5Division of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USADivision of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USATorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USASmart Biomolecules, Inc. 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USADivision of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USATorrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USAThe screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library TPI-1955 arranged on four sets of sublibraries (26 + 26 + 26 + 40), totaling 120 samples for testing provided information about the most important groups of each variable position in the TPI-1955 library containing 738,192 unique compounds. The parallel synthesis of the individual compounds derived from the deconvolution of the positional scanning library led to the identification of active selective antiplasmodial pyrrolidine bis-cyclic guanidines.https://www.mdpi.com/1420-3049/24/6/1100heterocyclic peptidomimeticsparallel synthesiscombinatorial chemistryguanidinessolid-phase synthesisantiplasmodialmalaria |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
David L. Perry Bracken F. Roberts Ginamarie Debevec Heather A. Michaels Debopam Chakrabarti Adel Nefzi |
| spellingShingle |
David L. Perry Bracken F. Roberts Ginamarie Debevec Heather A. Michaels Debopam Chakrabarti Adel Nefzi Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries Molecules heterocyclic peptidomimetics parallel synthesis combinatorial chemistry guanidines solid-phase synthesis antiplasmodial malaria |
| author_facet |
David L. Perry Bracken F. Roberts Ginamarie Debevec Heather A. Michaels Debopam Chakrabarti Adel Nefzi |
| author_sort |
David L. Perry |
| title |
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries |
| title_short |
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries |
| title_full |
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries |
| title_fullStr |
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries |
| title_full_unstemmed |
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries |
| title_sort |
identification of bis-cyclic guanidines as antiplasmodial compounds from positional scanning mixture-based libraries |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2019-03-01 |
| description |
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library TPI-1955 arranged on four sets of sublibraries (26 + 26 + 26 + 40), totaling 120 samples for testing provided information about the most important groups of each variable position in the TPI-1955 library containing 738,192 unique compounds. The parallel synthesis of the individual compounds derived from the deconvolution of the positional scanning library led to the identification of active selective antiplasmodial pyrrolidine bis-cyclic guanidines. |
| topic |
heterocyclic peptidomimetics parallel synthesis combinatorial chemistry guanidines solid-phase synthesis antiplasmodial malaria |
| url |
https://www.mdpi.com/1420-3049/24/6/1100 |
| work_keys_str_mv |
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