Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries
The screening of more than 30 million compounds derived from 81 small molecule libraries built on 81 distinct scaffolds identified pyrrolidine bis-cyclic guanidine library (TPI-1955) to be one of the most active and selective antiplasmodial libraries. The screening of the positional scanning library...
Main Authors: | David L. Perry, Bracken F. Roberts, Ginamarie Debevec, Heather A. Michaels, Debopam Chakrabarti, Adel Nefzi |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/6/1100 |
Similar Items
-
Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives
by: Liliane Abodo Onambele, et al.
Published: (2015-08-01) -
Mechanochemical synthesis of thioureas, ureas and guanidines
by: Vjekoslav Štrukil
Published: (2017-09-01) -
Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
by: Gijs Koopmanschap, et al.
Published: (2014-03-01) -
A systematic review on anti-malarial drug discovery and antiplasmodial potential of green synthesis mediated metal nanoparticles: overview, challenges and future perspectives
by: Loick P. Kojom Foko, et al.
Published: (2019-10-01) -
Synthesis and characterization of azo-guanidine based alcoholic media naked eye DNA sensor
by: Ataf Ali Altaf, et al.
Published: (2016-01-01)