Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation

Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation

Abstract Background Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shar...

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Bibliographic Details
Main Authors: Mayilaadumveettil Nishana, Caryn Ha, Javier Rodriguez-Hernaez, Ali Ranjbaran, Erica Chio, Elphege P. Nora, Sana B. Badri, Andreas Kloetgen, Benoit G. Bruneau, Aristotelis Tsirigos, Jane A. Skok
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Biology
Subjects:
CTCF
CTCFL
Cohesin
Loop extrusion
3D chromatin architecture
Gene regulation
Online Access:http://link.springer.com/article/10.1186/s13059-020-02024-0

Internet

http://link.springer.com/article/10.1186/s13059-020-02024-0

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