Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum levels of Orm1 were observed in patients afte...

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Bibliographic Details
Main Authors: Xian-Yang Qin, Mitsuko Hara, Erik Arner, Yoshikuni Kawaguchi, Ikuyo Inoue, Hideki Tatsukawa, Yutaka Furutani, Keisuke Nagatsuma, Tomokazu Matsuura, Feifei Wei, Jun Kikuchi, Hideko Sone, Carsten Daub, Hideya Kawaji, Timo Lassmann, Masayoshi Itoh, Harukazu Suzuki, Piero Carninci, Yoshihide Hayashizaki, Norihiro Kokudo, Alistair R.R. Forrest, Soichi Kojima
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:EBioMedicine
Subjects:
Orosomucoid-1
Hepatocyte proliferation
Lipocalin
Cell cycle
Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417303614

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http://www.sciencedirect.com/science/article/pii/S2352396417303614

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