Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

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Abstract Background Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are probably involved. We focused on bone morphogenetic protein (BMP)-2, -4, and -7...

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Bibliographic Details
Main Authors: Anne Briolay, Alaeddine El Jamal, Paul Arnolfo, Benoît Le Goff, Frédéric Blanchard, David Magne, Carole Bougault
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Arthritis Research & Therapy
Subjects:
Spondyloarthritis
BMPs
Ossification
Stretch
Cytokine
Enthesis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02330-9

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http://link.springer.com/article/10.1186/s13075-020-02330-9

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