Apoptotic caspases cut down the immunogenicity of radiation

Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as p...

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Bibliographic Details
Main Authors: Aitziber Buqué, Maria Esperanza Rodriguez-Ruiz, Jitka Fucikova, Lorenzo Galluzzi
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1655364