The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling

The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced apoptosis of HSC-T6 cells. Pin inhibited the viabi...

Full description

Bibliographic Details
Main Authors: Liang-Mou Kuo, Po-Jen Chen, Ping-Jyun Sung, Yu-Chia Chang, Chun-Ting Ho, Yi-Hsiu Wu, Tsong-Long Hwang
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Marine Drugs
Subjects:
hepatic stellate cells
Pinnigorgia sp.
ROS
apoptosis
caspase-3
MAPK
Online Access:http://www.mdpi.com/1660-3397/16/1/19

Internet

http://www.mdpi.com/1660-3397/16/1/19

Similar Items