Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function

Small heat shock proteins (HSPBs) contain intrinsically disordered regions (IDRs), but the functions of these IDRs are still unknown. Here, we report that, in mammalian cells, HSPB2 phase separates to form nuclear compartments with liquid-like properties. We show that phase separation requires the d...

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Bibliographic Details
Main Authors: Federica F. Morelli, Dineke S. Verbeek, Jessika Bertacchini, Jonathan Vinet, Laura Mediani, Sandra Marmiroli, Giovanna Cenacchi, Milena Nasi, Sara De Biasi, Jeanette F. Brunsting, Jan Lammerding, Elena Pegoraro, Corrado Angelini, Rossella Tupler, Simon Alberti, Serena Carra
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
small HSPs
phase transition
lamin-A/C
nucleus
congenital myopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311105

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http://www.sciencedirect.com/science/article/pii/S2211124717311105

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