Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients

Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients

Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) c...

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Main Authors: Isaac Almendros, Miguel Ángel Martínez-García, Francisco Campos-Rodríguez, Erica Riveiro-Falkenbach, José L. Rodríguez-Peralto, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernández Blasco, Jose Bañuls Roca, Eusebi Chiner Vives, Alicia Sánchez-de-la-Torre, Jorge Abad-Capa, Josep Maria Montserrat, Amalia Pérez-Gil, Valentín Cabriada-Nuño, Irene Cano-Pumarega, Jaime Corral-Peñafiel, Trinidad Diaz-Cambriles, Olga Mediano, Joan Dalmau-Arias, Ramon Farré, David Gozal, On Behalf of the Spanish Sleep Network, Elidia Molina Herrera, Rosa M. García Martín, Maria Niveiro de Jaime, Sara Moreno, Ferran Barbé Ilia, Manuel Sánchez de la Torre, Esther de Eusebio, Pedro Landete, Manuel Moragón Gordon, Eva Arias, Fernando Masa, Carlos González Herrada, Cristina Carrera, Aida Muñoz Ferrer, Aram Boada, Ana Fortuna, Mercé Mayos, Jesús Gardeazabal García
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neurology
Subjects:
melanoma
intermittent hypoxia
obstructive sleep apnea
hypoxia-inducible factor
vascular endothelial growth factor
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00272/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00272/full

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