A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke

Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune cells and S1P receptors (S1P<sub>R</sub>). Using a C57BL/6 mo...

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Bibliographic Details
Main Authors: Alexandra Lucaciu, Hannah Kuhn, Sandra Trautmann, Nerea Ferreirós, Helmuth Steinmetz, Josef Pfeilschifter, Robert Brunkhorst, Waltraud Pfeilschifter, Julien Subburayalu, Rajkumar Vutukuri
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
sphingosine 1-phosphate
regulatory T helper cells
stroke
sphingosine kinase
sphingosine 1-phosphate receptor
ceramides
Online Access:https://www.mdpi.com/1422-0067/21/17/6242

Internet

https://www.mdpi.com/1422-0067/21/17/6242

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