Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G

APOBEC3A and APOBEC3G cytidine deaminases inhibit viruses and endogenous retrotransposons. We recently demonstrated the novel cellular C-to-U RNA editing function of APOBEC3A and APOBEC3G. Both enzymes deaminate single-stranded DNAs at multiple TC or CC nucleotide sequences, but edit only a select s...

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Bibliographic Details
Main Authors: Shraddha Sharma, Bora E. Baysal
Format: Article
Language:English
Published: PeerJ Inc. 2017-12-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/4136.pdf