Mutational profile of GNAQQ209 in human tumors.

Mutational profile of GNAQQ209 in human tumors.

<h4>Background</h4>Frequent somatic mutations have recently been identified in the ras-like domain of the heterotrimeric G protein alpha-subunit (GNAQ) in blue naevi 83%, malignant blue naevi (50%) and ocular melanoma of the uvea (46%). The mutations exclusively affect codon 209 and resu...

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Main Authors: Simona Lamba, Lara Felicioni, Fiamma Buttitta, Fonnet E Bleeker, Sara Malatesta, Vincenzo Corbo, Aldo Scarpa, Monica Rodolfo, Margaret Knowles, Milo Frattini, Antonio Marchetti, Alberto Bardelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19718445/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19718445/pdf/?tool=EBI

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