Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.

Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.

Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years from the onset of symptoms. Tirasemtiv is a fast s...

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Bibliographic Details
Main Authors: Darren T Hwee, Adam Kennedy, Julie Ryans, Alan J Russell, Zhiheng Jia, Aaron C Hinken, David J Morgans, Fady I Malik, Jeffrey R Jasper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4013064?pdf=render

Internet

http://europepmc.org/articles/PMC4013064?pdf=render

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