Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism

Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism

Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), by inducing the production of immunomodulatory molecules, e.g., IL-10. In an effort to find the upst...

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Bibliographic Details
Main Authors: Yao-Juan Chu, Wen-Di Ma, Rodolfo Thome, Jie-Dan Ping, Fang-Zhou Liu, Meng-Ru Wang, Ming-Liang Zhang, Guangxian Zhang, Lin Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
matrine
multiple sclerosis
experimental autoimmune encephalomyelitis
IFN-β
IL-10
IL-27
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.569530/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.569530/full

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