Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation

The function and consequences of alternative polyadenylation (APA) in stressed cells are largely unclear. Here, the authors show that stress-induced mRNA degradation depends on 3′UTR length and that APA-mediated 3′UTR shortening is an adaptive stress response mechanism for selective transcript stabi...

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Bibliographic Details
Main Authors: Dinghai Zheng, Ruijia Wang, Qingbao Ding, Tianying Wang, Bingning Xie, Lu Wei, Zhaohua Zhong, Bin Tian
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04730-7

Internet

https://doi.org/10.1038/s41467-018-04730-7

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