Interaction of clozapine with metformin in a schizophrenia rat model

Abstract The low efficacy of antipsychotic drugs (e.g., clozapine) for negative symptoms and cognitive impairment has led to the introduction of adjuvant therapies. Because previous data suggest the procognitive potential of the antidiabetic drug metformin, this study aimed to assess the effects of...

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Bibliographic Details
Main Authors: G. Horvath, G. Kis, G. Kekesi, A. Büki, L. G. Adlan, E. Szűcs, H. El Heni, S. Benyhe
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96478-2