Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling

Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling

Cepharanthine (CEP) is a potential candidate for treatment of cerebral ischemia/reperfusion (I/R) injury, due to its anti-inflammatory and anti-oxidative properties. To investigate the effect of CEP on cerebral I/R injury, we established a mouse model of transient middle cerebral artery occlusion (t...

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Bibliographic Details
Main Authors: Jie Zhao, Xiangyu Piao, Yue Wu, Shanshan Liang, Fang Han, Qian Liang, Shujuan Shao, Dewei Zhao
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
cepharanthine
ischemia/reperfusion
microglia
NLRP3-inflammasome
oxidative stress
12/15-LOX
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303437

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http://www.sciencedirect.com/science/article/pii/S0753332220303437

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