Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats

Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats

Background: Accumulating evidence suggests that the polymerase I and transcript release factor (PTRF), a key component of the caveolae structure on the plasma membrane, plays a pivotal role in suppressing the progression of colorectal cancers. However, the role of PTRF in the development of function...

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Bibliographic Details
Main Authors: Hui-hui Zhou, Ye-ming Zhang, Sheng-peng Zhang, Qi-xiang Xu, Ya-qing Tian, Ping Li, Di Cao, Yong-qiu Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
polymerase I and transcript release factor
post-infectious irritable bowel syndrome
TLR4 signaling
ERK
JNK
p38
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.724410/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.724410/full

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