A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N pr...

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Bibliographic Details
Main Authors: Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Xiaoxue Chen, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Guanmin Jiang, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23036-9

Internet

https://doi.org/10.1038/s41467-021-23036-9

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