Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

Platelet-derived growth factor receptor β (PDGFRβ) is upregulated in most of solid tumors. It is expressed by pericytes/smooth muscle cells, fibroblast, macrophage, and certain tumor cells. Several PDGF receptor-related antagonists are being developed as potential antitumor agents and have demonstr...

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Bibliographic Details
Main Authors: Juqun Shen, Marie Danielle Vil, Marie Prewett, Chris Damoci, Haifan Zhang, Huiling Li, Xenia Jimenez, Dhanvanthri S. Deevi, Michelle Iacolina, Anthony Kayas, Rajiv Bassi, Kris Persaud, Anna Rohoza-Asandi, Paul Balderes, Nick Loizos, Dale L. Ludwig, James Tonra, Larry Witte, Zhenping Zhu
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558609801164

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http://www.sciencedirect.com/science/article/pii/S1476558609801164

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