Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent

Four Janus kinases (JAKs) (JAK1, JAK2, JAK3, TYK2) and seven signal transducers and activators of transcription (STATs) (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6) mediate the signal transduction of more than 50 cytokines and growth factors in many different cell types. Located intracellular...

Full description

Bibliographic Details
Main Authors: Alessia Alunno, Ivan Padjen, Antonis Fanouriakis, Dimitrios T. Boumpas
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
systemic lupus erythematosus
Janus kinase
protein tyrosine kinases
STAT
baricitinib
Online Access:https://www.mdpi.com/2073-4409/8/8/898

Internet

https://www.mdpi.com/2073-4409/8/8/898

Similar Items