Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

Cardiovascular disease is the leading cause of morbidity/mortality worldwide. Metformin is the first therapy offering cardioprotection in type 2 diabetes and non-diabetic animals with unknown mechanism. We have shown that metformin improves angiogenesis via affecting expression of growth factors/ang...

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Bibliographic Details
Main Authors: Sherin Bakhashab, Farid Ahmed, Hans-Juergen Schulten, Fahad W. Ahmed, Michael Glanville, Mohammed H. Al-Qahtani, Jolanta U. Weaver
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
cardiovascular disease
ischemia
diabetes
VEGF signaling
Online Access:http://www.mdpi.com/1422-0067/19/1/293

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http://www.mdpi.com/1422-0067/19/1/293

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