The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease
Background. Oxidative stress has been implicated in the pathogenesis of many diseases, including Parkinson’s disease. Large protein aggregates may be produced after the breakdown of the proteostasis network due to overt oxidative stress. Meanwhile, brain volume loss and neuropsychiatric deficits are...
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2021-01-01
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2021/3666327 |
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doaj-2db154d6e8594894ae251324f775a6152021-08-30T00:00:26ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/3666327The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s DiseasePei-Chin Chen0Chiun-Chieh Yu1Yueh-Sheng Chen2Cheng-Hsien Lu3Shan-Ho Chan4Kun-Hsien Chou5Mei-Hsiu Chen6Meng-Hsiang Chen7Wei-Che Lin8Department of Diagnostic RadiologyDepartment of Diagnostic RadiologyDepartment of Diagnostic RadiologyChang Gung University College of MedicineDepartment of Medical Imaging and RadiologyBrain Research CenterDepartment of Beauty ScienceDepartment of Diagnostic RadiologyDepartment of Diagnostic RadiologyBackground. Oxidative stress has been implicated in the pathogenesis of many diseases, including Parkinson’s disease. Large protein aggregates may be produced after the breakdown of the proteostasis network due to overt oxidative stress. Meanwhile, brain volume loss and neuropsychiatric deficits are common comorbidities in Parkinson’s disease patients. In this study, we applied a mediation model to determine the potential influences of oxidative stress-related plasma abnormal protein aggregate levels on brain volume and neuropsychiatric consequences in Parkinson’s disease. Method. 31 patients with PD and 24 healthy controls participated in this study. The PD patients were further grouped according to the presentation of cognitive decline or not. All participants received complete examinations to determine plasma abnormal protein aggregates levels, brain volume, and neuropsychiatric performance. The results were collected and analyzed in a single-level three-variable mediation model. Results. Patients with PD cognitive decline exhibited higher plasma NfL levels, decreased regional brain volume, and poor neuropsychiatric subtest results compared with PD patients with normal cognition, with several correlations among these clinical presentations. The mediation model showed that the superior temporal gyrus completely mediated the effects of elevated plasma NfL levels due to the poor psychiatric performance of picture completion and digit span. Conclusion. This study provides insight into the effects of oxidative stress-related plasma abnormal protein aggregate levels on regional brain volume and neuropsychiatric consequences in Parkinson’s disease patients.http://dx.doi.org/10.1155/2021/3666327 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pei-Chin Chen Chiun-Chieh Yu Yueh-Sheng Chen Cheng-Hsien Lu Shan-Ho Chan Kun-Hsien Chou Mei-Hsiu Chen Meng-Hsiang Chen Wei-Che Lin |
spellingShingle |
Pei-Chin Chen Chiun-Chieh Yu Yueh-Sheng Chen Cheng-Hsien Lu Shan-Ho Chan Kun-Hsien Chou Mei-Hsiu Chen Meng-Hsiang Chen Wei-Che Lin The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease Oxidative Medicine and Cellular Longevity |
author_facet |
Pei-Chin Chen Chiun-Chieh Yu Yueh-Sheng Chen Cheng-Hsien Lu Shan-Ho Chan Kun-Hsien Chou Mei-Hsiu Chen Meng-Hsiang Chen Wei-Che Lin |
author_sort |
Pei-Chin Chen |
title |
The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease |
title_short |
The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease |
title_full |
The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease |
title_fullStr |
The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease |
title_full_unstemmed |
The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease |
title_sort |
potential effects of oxidative stress-related plasma abnormal protein aggregate levels on brain volume and its neuropsychiatric consequences in parkinson’s disease |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Background. Oxidative stress has been implicated in the pathogenesis of many diseases, including Parkinson’s disease. Large protein aggregates may be produced after the breakdown of the proteostasis network due to overt oxidative stress. Meanwhile, brain volume loss and neuropsychiatric deficits are common comorbidities in Parkinson’s disease patients. In this study, we applied a mediation model to determine the potential influences of oxidative stress-related plasma abnormal protein aggregate levels on brain volume and neuropsychiatric consequences in Parkinson’s disease. Method. 31 patients with PD and 24 healthy controls participated in this study. The PD patients were further grouped according to the presentation of cognitive decline or not. All participants received complete examinations to determine plasma abnormal protein aggregates levels, brain volume, and neuropsychiatric performance. The results were collected and analyzed in a single-level three-variable mediation model. Results. Patients with PD cognitive decline exhibited higher plasma NfL levels, decreased regional brain volume, and poor neuropsychiatric subtest results compared with PD patients with normal cognition, with several correlations among these clinical presentations. The mediation model showed that the superior temporal gyrus completely mediated the effects of elevated plasma NfL levels due to the poor psychiatric performance of picture completion and digit span. Conclusion. This study provides insight into the effects of oxidative stress-related plasma abnormal protein aggregate levels on regional brain volume and neuropsychiatric consequences in Parkinson’s disease patients. |
url |
http://dx.doi.org/10.1155/2021/3666327 |
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