Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway

Stimulation of GLP-1 Receptor Inhibits Methylglyoxal-Induced Mitochondrial Dysfunctions in H9c2 Cardiomyoblasts: Potential Role of Epac/PI3K/Akt Pathway

Accumulation of methylglyoxal (MG) contributes to oxidative stress, apoptosis, and mitochondrial dysfunction, leading to the development of type 2 diabetes and cardiovascular diseases. Inhibition of mitochondrial abnormalities induced by MG in the heart may improve and delay the progression of heart...

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Bibliographic Details
Main Authors: Narawat Nuamnaichati, Supachoke Mangmool, Nipon Chattipakorn, Warisara Parichatikanond
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Epac
exendin-4
GLP-1 receptor
methylglyoxal
mitochondrial dysfunction
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00805/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00805/full

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